Signals by drug and event

All (drug, event) pairs flagged by ≥2 of 4 disproportionality methods (GPS/EBGM, PRR, ROR, IC) over the AERS 2004–2012 era. The splash shows the top 2000 by Adj EB05 (peak EB05 after Weber-effect shrinkage for drugs <5 years on market at the time); use search to find any other pair. Default filter: Novel pairs with ≥3 quarters of signal. Click any row to see the time-course plot and the label cross-check.

Novel column: “novel” means the event is absent from the drug’s current FDA label — boxed warning, contraindications, warnings, adverse reactions, indications — after MedDRA-synonym expansion (UMLS CUI) and British↔American + clinical-term normalization. Note this compares historical AERS-era signals to current labels: a drug whose label was updated 2013–2025 in response to a real signal will show as “known” here. Medication- error, product-quality, and administration PTs are hidden. Class co-flags = number of other drugs in the same ATC4 class that also flag this event across the full pair universe (1 = drug-specific; ≥3 suggests class effect). The default view hides pairs with ≥3 class co-flags as likely class effects; clear the Class co-flags column filter to see them. Treat remaining rows as historical hypotheses, not confirmed novel associations.